Abstract: An efficient and controlled Pd−catalyzed synthesis of attached-ring bis(dihydropyran) fused cyclobutenes via alkyne dimerization followed by double [2+2] cyclization of the resulting bis(allenyne) in a domino sequence has been accomplished.

Abstract: Three hexadentate Schiff base ligands were obtained by condensation of 3-ethoxy-2-hydroxybenzaldehyde and different diamines (1,2-diaminoethane, 1,2-diaminopropane, 1,2-diamino-2-metylpropane) to yield H2Ln (H2L1, H2L2 and H2L3, respectively). The ligands have been characterised by elemental analysis, IR, and 1H and 13C NMR spectroscopic techniques, mass spectrometry (ES) and X-ray diffraction.

Abstract: Fluorescent benzo[a]phenoxazinium chlorides with dipropyl-, dioctyl- didecyl- and didodecyl-chains as the amino substituents of the 9-positions of the tetracyclic system were synthesised in moderate to good yields. All the compounds absorbed in the wavelength range of 638-641 nm and emitted at 673 or 676 nm with quantum yields of 0.17-0.19 in ethanol.

Abstract: The silylcupration of allene has emerged as a useful tool for the synthesis of functionalized allylsilanes which have been used in the synthesis of different-sized carbocycles. We now described the preparation of allylsilane-allylcuprate intermediates by homologation reaction with iodomethylzinc iodide and their reaction with different electrophiles.

Abstract: Thiocarbamic acid [(furan-2-yl) ethylidene] hydrazide has been synthesized by the reaction between 2-acetylfuran and thiosemicarbazide in 1:1 molar ratio under ball milling conditions. The title compound has been characterized by FT-IR and elemental analysis.

Abstract: N-(3(5)-Aryl-1,2,4-triazol-5(3)-yl)-N'-carbethoxythioureas were prepared from ethoxycarbonyl isothiocyanate and 3(5)-amino-5(3)-aryl-1,2,4-triazoles. The annular prototropic tautomerism in the compounds was investigated by 1H NMR in DMSO solution. The tautomeric preferences depended on electronic properties of substituents on the phenyl ring and were well correlated with their Hammett constant values.

Abstract: Oxidative deprotection of benzylic silyl ethers has been carried out using nitrogen dioxide gas to the corresponding aldehydes and ketones in quantitative yields.

Abstract: Mono-Boc-protection of bispidine was achieved using equimolar amounts of TFA and Boc2O with iodine as catalyst.

Abstract: 2-(2-hydroxyphenyl)-1,3-bis[4-(2-hydroxyphenyl)-3-azabut-3-enyl]-1,3-imidazolidine (H3L) was obtained with high purity by Schiff's condensation between 5-bromosalicyaldehyde and triethylenetetramine. Its recrystallisation in methanol yields single crystals suitable for X-ray diffraction studies. H3L crystallises in the monoclinic system, space group P21/c, with a = 21.641(3) Å, b = 11.1217(14) Å, c = 11.4156(15) Å and β = 90.016 º.

Abstract: The first hydroxilated series of coumarin-chalcone derivatives has been synthesize starting from the corresponding salicyl aldehyde and β-ketoester precursors by a Knoevenagel reaction in order to obtain the methoxy derivatives which have been further hydrolyzed with a Lewis acid.

Abstract: Phase transfer catalysis (PTC) is an important modern synthetic method where reagents are located in different phases. Generally, it is transfer of inorganic reagent (base or nucleophile) from aqueous medium or solid phase to organic phase. Current catalysts for „classic" PTC are –onium salts (N, P, S), macrocyclic polyesters (crown-ethers), aza- -macrobicyclic ethers (cryptands), polyethylenglycols (PEGs) and their dimethylethers. Both in laboratory and industry, the most widely used catalysts are ammonium salts for their good price and availability. The other trend which is implementing within the frame of „Chemistry for sustainable development" are supported catalysts. Generally catalyst is bound on inorganic or organic polymer support and the system is insoluble in water and organic solvents as well. Supported catalyst can be easily separated from the reaction mixture and it can be reused again. Piperazine (A) as secondary cyclic 1,4-diamine offers two functional centers on its nitrogen atoms – one for preparation of quaternary catalytical place and second for immobilization on solid support, organic polymer.

Abstract: A novel approach based on combinations of various water compatible Lewis acids and L-proline cocatalysts has been evaluated for the direct asymmetric aldol reaction. From this screening zinc (II) chloride salts lead to the highest stereoselectivities. Optimized catalytic conditions (Catalytic system : L-proline : 20 (percent) / ZnCl2 : 10 (percent) - Solvent mixture : DMSO/H2O – 8 : 2) give anti aldol product with improved enantioselectivity (>99 (percent) e.e.) compared to a moderately stereoselective procedure based on proline activation only.

Abstract: It was found that tetraethylammonium hydroxide reacts with N-hydroxyphthalimide as a nucleophile rather than a base to afford tetraethylammonium 2-(hydroxycarbamoyl)benzoate (TEAHCB). The TEAHCB was found to be able to efficiently catalyze the cyanosilylation of a wide range of carbonyl compounds as a bifunctional organocatalyst at very low catalyst loading (0.2 mol(percent)).

Abstract: porphyrins were prepared inside the large pores of the zeolite NaY by a process of sequential introduction of components followed by assembly inside the void space of the zeolite. The appropriate process chosen for the porphyrin synthesis was using the propionic acid solvent for reaction between pyrrole and benzaldehyde and this solvent was not destructive for zeolite. The resulting materials were purified by Soxhlet extractor. The zeolite-included porphyrins were identified for studies using UV-Vis and FTIR Spectroscopy and SEM techniques.

Abstract: We describe herein a novel synthetical application of shikimic acid, which consist of its transformation into (3R,4S,5R,7S)-7-(hydroxymethyl)azepane-3,4,5-triol.

Abstract: A one- pot three-component reaction of 2-aminobenzothiazole, 2-naphthol, and aldehydes has efficiently been carried out in the presence of Wells-Dawson heteropolyacid (H6P2W18O62 _ 24H2O) in water at 60 °C to form the corresponding 2'-aminobenzothiazolomethylnaphthols in high yields.

Abstract: A new proton sponge 1,8-bis(tetramethylguanidino)naphthalene (TMGN) was utilized for the alkylation of benzoic acid by iodomethane in a continuous flow microsystem. Using this set-up, kinetics of the reaction was determined in different mixing strategies and the Hammett reaction constant was measured. Good performance and efficiency of this procedure were confirmed through several preparative studies.

Abstract: Evaluation of a new proton sponge, bis-1,1,8,8-(tetramethylguanidino)naphtalene (TMGN), in substituted phenols O-alkylation by methyl iodide in DMF has been studied. Kinetic measurements were performed in N,N-dimethylformamide-d7 and followed by 1H NMR using stoichiometric amounts of reagents. Plot of the results shows that the reaction follows an almost perfect second order rate law. However the Hammett plots for substituted phenols are not linear but bell shaped. In order to separate the deprotonation and alkylation contribution to the kinetics, deprotonation of phenols by TMGN has been investigated by quantitative 13C NMR. By combining these data a linear Hammett plot with a negative slope was obtained for the alkylation step and substituted phenol acidity constants in DMF, not accessible by NMR measurements, were determined which are in agreement with literature data.

Abstract: We have developed a new catalytic asymmetric method for the synthesis of highly functionalized non-racemic chiral alkyl halides using Kharasch addition in good yields and moderate enantioselectivities.

Abstract: A combination of tetrachlorosilane (TCS) and phenol in dichloromethane was found to be an efficient reagent for hydrochlorination of α,β- unsaturated ketones to afford the corresponding β-chloroketones in good yield at ambient temperature.

Abstract: A series of N-substituted-3,4,5,6-tetrachlorophthalimides were prepared by a novel sequential reaction of trichloroacetimidate 3 with C-nucleophiles in the presence of TMSOTf. The nucleophiles include arenes, alkenes and active methylene to give the imidomethylation product of 3,4,5,6-tetrachlorophthalimide 5, 7, 9 and 11, respectively.

Abstract: A fluorescent pyrenylmethyl moiety was coupled to the N-terminus of a series of catecholamines. The behaviour of the corresponding fluorescent conjugates towards photocleavage was evaluated by irradiation in MeOH/HEPES buffer (80:20) solution, in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV monitoring.

Abstract: We wish to report synthesis carbamates using Preyssler heteropolyacid, in absence of solvent and at room temperature, in green conditions.This synthesis was in mild conditions, ecofrienly and environmentally friendly, clean and with a easy work-up.

Abstract: 2-nitrobenzofuran is studied in Diels-Alder reactions under thermal conditions. A concise synthesis of dibenzofurans has been developed via cycloaddition reactions.

Abstract: Flexible routes for the stereoselective synthesis of a variety of structurally diverse 1-, 3- or 4-alkyl and aryl-tetrahydrobenzo[c]azepines have been developed. The key steps are the highly diastereoselective 1,2-addition process or metallation/alkylation sequence applied to stereopure hydrazones. Subsequent cyclomethylenation or ringclosing metathesis reaction to secure the formation of the seven-membered azaheterocycle ring system complete the assembly of the targeted titled compounds.

Abstract: The development of an unprecedented methodology based upon direct photolysis of N,N-disubstituted hydrazides to secure N-N bond cleavage and to trigger off the formation of NH free lactams has been disclosed.

Abstract: A new homologous series of mesogen, 6-ethoxy-2-(4- alkanoyloxybenzylideneamino)benzothiazoles with even number of carbons (n = 6, 8, 10, 12, 14, 16, 18) at terminal ester chain have been successfully synthesized and isolated. The structure of the title compound was confirmed using elemental analysis and various spectroscopic techniques including FT-IR, 1H NMR and 13C NMR and EI-MS. Phase transition temperatures and thermal data were determined using differential scanning calorimetry. The textures of mesophases were observed under optical polarizing microscope attached with a Linkam hotstage. All the compounds are enantiotropic liquid crystals. While n-hexanoyloxy and n-octanoyloxy derivatives exhibited nematic, ndecanoyloxy to n-octadecanoyloxy derivatives showed smectic C and nematic phases.

Abstract: With of reaction of 5-amino-pyrazole-4-carbonitrile derivative and using from supported Preyssler heteropolyacid catalyst in a series from reactions prepared a several new pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-e][1,4]diazepine, pyrazolo[3,4- d][1,2,3]triazine and pyrolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives.

Abstract: We wish to report reaction of various carbamates and oxazolidinones with carboxylic acid anhydrides in the presence of Wells-Dawson heteropolyacid catalysis. The N-acylation was carried out in presence heteropolyacid catalyst and gave the corresponding N-acyl products in good yields under solvent-free, green conditions. In this acylation used of Carboxylic acids and anhydride as acylating agents.

Abstract: Cyano functionalized 6-methoxyquinolin-2-ones were synthesized from malonic acid derivatives and p-anisidines in multistep reactions via 4-chloro-6-methoxyquinolin-2-ones. Introduction of cyano substituents resulted in 3,4-dicyano-6-methoxyquinolin-2-ones or 4- cyano-6-methoxyquinolin-2-ones, depending on the substituents in position 3 and 1. The study of the fluorescence properties of 3,4-dicyano-6-methoxyquinolone showed emission values up to 550 nm (black curve) combined with large Stoke's shifts , whereas 4-cyano-6- methoxyquinolones gave lower values (e.g. blue curve) comparable to earlier findings.

Abstract: An efficient strereocontrolled synthesis of substituted oxazolidin-2-one synthon 11 as the key intermediate in the synthesis of FTY720 analogues starting from the highly functionalized furanose scaffold 21 is reported.

Abstract: A series of novel bi-heterocyclic ethers, containing 4H-pyrido[1,2-a]pyrimidin-4-one along with other five and six-membered heterocyclic rings, was obtained utilizing ethyl [(4- oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy]acetate (1), [(4-oxo-4H-pyrido[1,2-a]pyrimidin-2- yl)oxy]-acetic acid (2) and/or [(4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy]acetohydrazide (3). Reaction of ester 1 with some ortho-hydroxy aldehydes furnished the corresponding pyridopyrimidyloxypyrones. Reaction of ester 1 or acid 2 with 1,2-diamines led to some imidazoles. Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3.

Abstract: A commercial cordierite sample showed a small catalytic activity in iso-propanol conversion carried out at 150-350 °C and no measurable activity in CO oxidation by O2. On the other hand, supporting NiO on Al2O3–modified cordierite resulted in the formation of an active solid that having good catalytic activity in iso-propanol conversion and CO oxidation by O2. These two reactions were carried out at 150-350 and 200 °C, respectively. The results revealed that the catalyst containing 5wt (percent) NiO showed the biggest activity in the alcohol conversion and acted as selective dehydration catalyst. The catalyst sample containing 20wt (percent) NiO exhibited a good activity in CO oxidation by O2 which decreased progressively by increasing its calcination temperature within 350-600 °C. Al2O3–treated cordierite dissolved a portion of NiO in its lattice which increased by increasing the calcination temperature within 350-600 °C.

Abstract: 0.2CuO/MgO solids prepared by impregnation method was calcined at 350 and 450 ºC. The effects of γ-rays (0.2-1.6 MGy) on its structure, surface and catalytic properties were investigated by using XRD, N2–adsorption at -196ºC and catalytic conversion of iso-propanol at 150-275 ºC using a flow technique. The results revealed that the investigated solids consisted of nano-sized MgO as a major phase beside CuO and trace amount of Cu2O. γ- Irradiation of the solids investigated exerted measurable changes on their surface and catalytic properties. These changes are dependent on the calcination temperature and dose of irradiation. The catalysts investigated acted as active dehydrogenation solids. The five yearsageing of different solids showed a limited influence on surface and catalytic properties indicating a good catalytic stability of the prepared solids.

Abstract: The reaction of enantiopure 3-azido-4-oxoazetidine-2-carbaldehyde with acetone was catalyzed by L-proline, to give the corresponding aldol adduct. This product was stereocontrolled cyclized by using intramolecular reductive amination achieving a new 4-hydroxypipecolic acid analogue with a bicyclic b-lactam structure.

Abstract: Platelet, tubular and herring-bone carbon nanofibres were doped with Pd under various conditions. The catalysts were analysed as to the Pd-content and as to the size distribution of the Pd particles. The Pd-doped carbon nanofibres were screened for their catalytic activity in the Suzuki-Miyaura cross coupling and in the Heck reaction.

Abstract: Estra-1,3,5(10),16-tetraene was converted to an estra-1',3',5'(10')- trieno(16',17':4,5)isoxazoline. The isoxazoline was transformed to a substituted 1- formylphenanthrene by the action of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ).

Abstract: A new fluorescent functionalized amino acid, 4-chloromethylcoumarin-6-yl-alanine, was used in the synthesis of an amino acid conjugate by coupling with a model N-protected alanine, through an ester linkage. The photophysical properties of the fluorescent conjugate are presented, as well as its behaviour towards photocleavage by irradiation in methanol/HEPES buffer (80:20) solution, in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV and 1H NMR monitoring.

Abstract: The novel functionalised oxygen heterocycle 4-(hydroxymethyl)-6-methoxy-2-oxo-2H-benzo[h]benzopyran was synthesised and used in the preparation of a fluorescent ß-alanine conjugate. In order to evaluate its photosensitivity, photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300 and 350 nm) was carried out and photocleavage kinetic data were obtained.