Abstract: Catalytic oxidation of cyclohexane by two metalloporphyrins {manganese and iron 5, 10, 15, 20-meso-tetrakis-(p-chlorophenyl) porhyrin}immobilized in mesoporous MCM-48 with TBHP in acetonitril was investigated. It was found that immobilization significantly enhances catalytic activity as compared to the homogenous system.

Abstract: A new kind of surfactants with chelating properties named N-Acyl ethylenediamine triacetate (N-acyl ED3A) of different hydrocarbon chain lengths were synthesized from anhydrous ethylene diamine, fatty acid chlorides (Capryloyl, Lauroyl, myristoyl, palmitoyl, stearoyl or oleoyl chloride) and chloroacetic acid. The chemical structures of the prepared compounds were confirmed using different spectroscopic techniques, primarily Fourier transform infrared spectroscopy and nuclear magnetic resonance. The surface properties including surface and interfacial tension, foaming height, emulsification power, calcium ion stability, stability to hydrolysis and critical micelle concentration (CMC) were determined. The trisodium N-acyl ethylenediamine triacetates have been found to combine the properties of strong surfactancy, extreme mildness with a high tolerance to water hardness, and ability to chelate metal ions, which indicates a promising application prospect in many fields.

Abstract: ZSM-11 samples were synthesized and treated with small amounts of Pt and Au substrates (1 & 4wt% metal). The effects of this treatment on the structural, textural, and catalytic properties of the employed zeolite were studied. The acidity of Pt and Au-containing ZSM-11 solids was determined. The techniques employed were XRD, pyridine adsorption using FTIR-technique, N2 adsorption at -196 ºC, and catalytic conversion of isopropyl alcohol at 110-275 ºC using a flow technique. The treatment of ZSM-11with Au and Pt-species resulted in a structure collapse of 23, 19 %, respectively without much affecting its crystallite size. The specific surface areas of zeolites decrease slightly by treatment with Pt and Au species while their microporosity increased from 79 to 91%. All catalysts investigated behaved as selective dehydration solids having activities which increased by treating with Pt or Au species. The samples treated with 4 wt% Pt showed the biggest activity. The selectivity towards propene formation was also found to increase by treatment with Pt or Au species.

Abstract: 3-Nitro-4-chloroquinoline 3 was converted to the azides 5/6. The azides were cyclized on thermolysis to furoxanes 7/8. Deoxygenation to furazane 9 was achieved by reaction with triphenylphosphane. The reaction conditions were studied by differential scanning calorimetry (DSC). The azides 5/6 gave with triphenylphosphane the phosphazenes 10/11, which were cleaved to the aminoquinolone 12

Abstract: Three new asymmetric Schiff base compounds, (E)-methyl 2-(2-(2-hydroxy-3-methoxybenzylideneamino)ethylamino)cyclopent-1-enecarbodithioate[H 2 cd3-OMesalen](1), (E)-methyl 2-(2-(3,5-di-tert-butyl-2-hydroxybenzylideneamino)ethylamino)cyclopent-1-enecarbodithioate[H 2 cd di tertbutsalen] (2) and (E)-methyl2-(2-(3-hydroxy-4-methoxybenzylideneamino)ethylamino)cyclopent-1-enecarbodithioate[H 2 cd4-OMesalen] (3) have been prepared. The compounds have been studied with IR, 1 H NMR, 13 C NMR and microanalysis. The crystal structure of (1) has been also determined.

Abstract: Efficient synthesis, besides other, of dibromide, diazide, diamine and diesters derived from (11R,12R)-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol (3), a chiral bicyclic diol with C 2 symmetry, was developed. Esterification of 3 with saturated and unsaturated carboxylic acids and acids chlorides leads to the corresponding normal-, olefinic- and acetylenic diesters in average yields of 81%. Also more efficient techniques for the preparation of starting diol 3 in higher yields as well as for a very simple separation of DCU from reactions carried out following DCC/DMAP method are described.

Abstract: The synthesis of symmetrical and non-symmetrical 4,6-disubstituted pyrimidines was performed by one-pot or stepwise palladium-catalyzed cross-coupling reactions respectively using indium reagents.

Abstract: Skin penetration enhancers are used in the formulation of transdermal delivery systems for drugs that are otherwise not sufficiently skin-permeable. The series of seven esters of 6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxoazepan-1-yl hexanoic acid as potential transdermal penetration enhancers was formed by multistep synthesis. The general synthetic approach of all newly synthesized compounds is presented. Structure confirmation of all generated compounds was accomplished by IR, ¹H, ¹³C NMR and HR-MS spectroscopy. All the prepared compounds were analyzed using RP-HPLC method for the lipophilicity measurement and their lipophilicity (log k) was determined.

Abstract: Iminosugars are one of the most interesting discoveries in the field of natural products recent years due to their promissing biological activity. We report synthesis of 1-deoxynojirimycin building block using D-glucose as the starting material and the [3,3]-sigmatropic aza-Claisen rearrangement as the key step of our synthesis.

Abstract: We present here the preparation of the precursor for stereoselective synthesis of (+)-lactacystin starting from D-glucose. The first step is conversion of D-glucose to 1,2:5,6-di-O-isopropylidene-α-D-gulofuranose. The second step is introduction of a methyl group at C5 and preparation of compound 9. This compound can be used as a precursor of target molecule of (+)-lactacystin

Abstract: Polymorphism of active pharmaceutical ingredients (APIs) gets increasing attention as an important physico-chemical parameter influencing bioavailability and stability of API and pharmaceuticals. Co-crystals of API with common pharmaceutical excipients become very important as a tool to tune up solubility and absorption. Bisphosphonates (e.g. alendronate, risedronate, ibandronate) are widely used in clinical practice. They are indicated for the treatment and prevention of osteoporosis. They are powerful inhibitors of bone resorption, but their gastrointestinal adsorption is only about 1% due to their high hydrophilicity. Some experiments were designed to prepare co-crystals of risedronate. In the present study various mixtures of risedronate and excipients were prepared. All the prepared mixtures (solid compounds) and/or new entities were analyzed by means of FT-NIR, FT-Raman spectroscopy and solid state NMR.

Abstract: The design and synthesis of new calamitic benzothiazole-based liquid crystals, 2-[4-(4-alkyloxybenzoyloxy)phenyl]benzothiazoles, are presented. The target compound was characterized using spectroscopic techniques, such as FT-IR, NMR (¹H & ¹³C), microanalysis and EI-MS. The liquid crystalline behaviours of these compounds were thoroughly examined by differential scanning calorimetry and polarizing optical microscope techniques. These materials exhibited enantiotropic nematic phase with high thermal stability. Smectic A phase starts to emerge as monotropic phase from C10 member and changes into enantiotropic phase from C12 and persists up to C16 members.

Abstract: 5- and 8-nitroquinolines are studied as dienophiles in polar thermal Diels-Alder reactions whit normal electron demand using several and structural different dienes, and chloroform as solvent media. A very strong electron-acceptor group, such as nitro group, push the dienophilic character of these heterocyclic compounds and owing to this substituent is easily extruded under thermal conditions. When the cited dienophiles were reacted with isoprene, 1-trimethylsilyloxy-1,3-butadiene and de Danishesfky diene, under different reaction conditions they showedtheir dienophilic character taking part in a normal demand DA cycloaddition reactions. These cycloaddition reactions were analyzed in presence of ionic liquids (IL´s). In this sense was used ethyl ammonium nitrate (NEA) as protic IL´s and another composed by 1-butyl-3-methyl-imidazolium [bmim] as the cation and tetrafluoroborate as the anion [BMIM] [BF₄]. The presence of IL´s improved the yields and the reaction conditions are softer.

Abstract: A comparative study of 6-methoxy-, 7-methoxy- and 6,7-dimethoxycarbostyrils revealed, that both, the 6 and the 7-methoxy group have different effects to the fluorescence properties of carbostyrils such as fluorescence wavelength, quantum yield and Stoke's shift. A further important influence is visible from the electron acceptor properties of the substituent in position 4

Abstract: the synthesized compounds are aryl/ 4-substituted Thiourea as evident by elemental and UV, IR and NMR spectral data.

Abstract: The ¹H, ¹³C and ¹⁵N NMR spectra, both in solution and in the solid state, of five 1,2-phenylenediamines have been recorded. Assignment of all the signals has been achieved and chemical shifts and coupling constants determined. When necessary homo- and heteronuclear 2D NMR experiments have been performed.

Abstract: In this study, immobilized Iron (III) complex of meso-tetrakis(p-chlorophenyl) porphyrin [Fe_III(TClPP)] on modified silica gel by 3-aminopropyl group has been used as a heterogeneous catalysts for oxidation of benzhydrol by t-butyl hydroproxide (TBH). The reaction was performed at room temperature to afford benzophenone in high yields and short reaction time. Furthermore, the catalyst can be reused for at least 3 reaction cycles without significant lose of its activity.

Abstract: The additives influence on the photochemical reactivity of 1,3-dinitrobenzoyleneurea was studied. Amines having different chemical nature, iso-propylic alcohol and sodium salt of mandelic acid proved to be efficient additive to activate the title compounds activity. The additive role is electron and/or H-atom transfer ability improving.

Abstract: Nano-OrderedZn-MCM-41 materials were synthesized using different zinc sources and applied for liquid phase Beckman rearrangement of 4-hydroxyacetophenone oxime to acetaminophen. The reaction conditions such as amount of the catalyst and solvent were optimized to afford acetaminophen in high yields. it Aprotic solvents with high dielectric constant are preferred for this transformation.

Abstract: Phenyl selenol and the zinc-selenolate PhSeZnCl can be conveniently employed for the stereospecific and stereoselective synthesis of vinyl selenides. These reactions occur with moderate to high yields and can be accomplished in eco-compatible conditions using a biphasic acidic system or directly an aqueous suspension.

Abstract: Mn(III) tetra (4-methoxyphenyl) porphyrin (MnTMePP) was synthesized inside the nanocages of zeolite-X according to "ship-in-bottle " model. MnTMePP was impregnated (MnP-NaX imp) and encapsulated (MnP-NaX) in the zeolite matrix and had been used as an active heterogeneous catalyst for thymol hydroxylation. The oxidation results were improved by immobilization of metalloporphyrin inside zeolitic faujasite in compression with homogeneous catalyst (MnTMePP). The hydroxylation reaction was performed at 25 ° C and atmosphere pressure by using H 2 O 2 / Ammonium acetate. All catalysts were characterized by X-ray diffraction (XRD) and Scanning electron microscopy (SEM) Ultraviolet-Visible (UV-Vis) spectroscopy analyses.

Abstract: A route for the preparation of five- and six-membered ring α/β - and α/γ-glycoamino acids is described starting from D-Glucose. The α/β glycoamino acids were synthesized using a DAST-promoted ring contraction as a key step followed by hydrolysis, acetylation, oxidation and attachment of the α-amino acid. The α/γ-glycoamino acids were synthesized by cleavage of the benzylidene protecting group as the first step, accompanied with subsequent oxidation, acetylation and attachment of the α-amino acid. At the present, we are focusing our attention in synthesizing these α/β-glycoamino acids at a higher scale by using other non-corrosive fluorinating agents.

Abstract: Benzaldehydes undergo Wittig olefination with alkoxycarbonylmethylidenephos­phorane in 10w% aqueous NaOH. The cinnamates are hydrolysed under the conditions and cinnamic acids are obtained after simple extractive work-up. Under the same conditions, benzaldehydes react with alkoxycarbonylbromomethy­lidenephosphorane to give arylpropiolic acids.

Abstract: A new convenient procedure for the bromination of aromatic side chains was efficiently achieved by using a combination of tetrachlorosilane (TCS) and N-bromosuccinimide (NBS) at ambient conditions.

Abstract: Esterification reaction of phthalic anhydride with 2-ethyl hexanol was investigated using sulfated titanium dioxide nano catalyst. The influence of reaction time, catalyst amount and alcohol/anhydride molar ratio was studied using a rotatable central composite design (CCD). The optimum values of factors were: 83 min for the time, 9 %wt catalyst, 9:1 alcohol:anhydride molar ratio. The maximum yield of 93% at optimum conditions was obtained.

Abstract: Ethyl 4-methyl-2-oxo-7-phenylthio-2,3,6,7-tetrahydro-1H-1,3-diazepine-5-carboxylate and/or ethyl 6-methyl-2-oxo-4-(phenylthiomethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained in the reaction of ethyl 4-chloromethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimi-dine-5-carboxylate with PhSNa or PhSK with or without PhSH, depending on the reagent ratio, reaction time or temperature, as a result of ring expansion and/or nucleophilic substitution. The reaction pathway was affected strongly by the basicity-nucleophilicity of the reaction media. The results obtained were confirmed by reactions of 4-mesyloxymethyl-6-methyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one with PhSNa/PhSH and ethyl 4-chloro-methyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate with NaCN/HCN or NaCH(COOEt)₂/CH₂(COOEt)₂.

Abstract: In the presence of strong bases (NaH, DBU, KOH), ethyl 4-chloromethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate and 4-mesyloxymethyl-6-methyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one are transformed into novel tricyclic compounds, diethyl 9-methyl-5-methylene-3,11-dioxo-2,3,4,5,6a,7,10,11-octahydro-1,6-methano[1,3]diazepino[1,7-e][1,3,5]-triazocine-6,8(1H)-dicarboxylate and 9-methyl-5-methylene-6,8-ditosyl-1,2,4,5,6,6a,7,10-octahydro-1,6-methano[1,3]diazepino[1,7-e][1,3,5]triazocine-3,11-dione, respectively.

Abstract: The parallel kinetic resolution of racemic secondary arylalkyl alcohols using an equimolar amount of quasi-enantiomeric active esters and zinc chloride is discussed. The levels of enantiomeric recognition were high leading to enantiomerically enriched alcohols in good yield.

Abstract: The four-membered spiro-heterocycles; ethyl cyano(1-methyl-2,4-dioxospiro{1,3-quinoline-3,4'-[1,3]dithietane}-4'-ylidene)- acetate 2a, -malononitrile 2b, -acetylacetone 2c and thiazetidine isomer 3 were prepared under phase transfer catalysis conditions (PTC). The thermal treatment of dithietanes 2a–c led to the bis-quinolinyl sulfide 4. Some interesting nucleophilic addition followed by cyclization reactions were carried out with the dithietane 2a to give the corresponding novel dispiro derivatives 5–8, 10–13, and 15.

Abstract: Several ionic liquids used as catalyst for three-component Mannich reactions of aldehydes, amines, and naphthols at room temperature. The used ionic liquids include 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF₄), 1-octyl-3- methylimidazolium tetrafluoro-borate ([Omim]BF₄), 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim]BF₄), butyl dimethylimidazolium tetrafluoroborate ([Bdmim]BF₄), 1-octyl-3-methylimidazolium nitrate ([Omim]NO₃), 1-methylimidazolium sulfuric acid ([Hmim]HSO₄) and 1-methylimidazolium trifluoroacetic acid ([Hmim] Tfa). Higher yields were obtained in the presence of [Hmim]Tfa in comparison with other ionic liquids.

Abstract: Elimination of 4 haloidbenzenes, benzoic acid and diphenyl spectral parameters from all investigated dependencies Dd_i^H–s and DCAP–s seems to be logically grounded. Such elimination is explained by specific behavior of this compounds in NMR ¹H spectra. In this connection R correlation coefficient essentially increases in all diagrams with above constants elimination.

Abstract: A homologous series of cholesteryl 4'-alkyloxybiphenyl-4-carboxylates (C_nH_2n+1OC₆H₄ C₆H₄COOCh, where Ch = cholesteryl) possessing different length of alkyl chain (n = 6, 8, 10, 12, 14, 16, 18) were synthesized. Phase transition temperatures and thermal parameters were obtained from differential scanning calorimetry. Observation under optical polarizing microscope revealed all the members of the series possessing SmA property. Additional mesophase was observed for lower members whereby the C6-14 derivatives displayed fan-shaped and oily streaks textures of cholesteric phase. The influence of structural changes on the mesomorphic properties is discussed.

Abstract: Synthesis and characterization of new amphiphilic azobenzenes with non ionic character is presented. The synthetic methodology is simple and versatile which allows the generation of molecular diversity from the same precursors in an easy way.

Abstract: A facile, one pot three-component procedure for the efficient synthesis of novel 2'-aminobenzimidazolomethylnaphtols derivatives was developed by the reaction of 2-aminobenzimidazole, 2- naphtol and aromatic aldehydes in the presence of L-proline under grinding and solvent free condition at room temperature.

Abstract: A new series of polyoxygenated amido isoborneols has been synthesized and tested on the enantioselective addition of diethylzinc to benzaldehyde and the results compared to a series of related amino isoborneols. The observed different behavior has been explained on the basis of catalytic quelates previously proposed by us

Abstract: The condensation of 3-methoxy or 3-ethoxy-2-hydroxybenzaldehyde and 1,2 diamine -2-methylpropane, to yield at the dianionic hexadentate Schiff base ligands H₂ Lⁿ (H₂ L¹ , H₂ L² respectively). The ligands have been characterised by elemental analysis, IR, ¹H and ¹³C NMR spectroscopies and mass spectrometry (ES). The crystal structure of the two ligands was solved by X-ray crystallography, revealing its ability to bind metal centres.

Abstract: Valine and phenylalanine were used as model amino acids for the synthesis of ester conjugates with a fused oxobenzopyran, in order to evaluate its applicability as a photocleavable protecting group for solution phase organic and peptide synthesis. The behaviour of the corresponding conjugates towards photocleavage was evaluated by irradiation in methanol/HEPES buffer (80:20) and acetonitrile/HEPES buffer (80:20) solutions, in a photochemical reactor at different wavelengths (300 and 350 nm), followed by HPLC/UV monitoring.

Abstract: In order to evaluate the application of new oxobenzopyrano[6,7-d]oxazoles as photocleavable protecting groups, a series of model alanine and β-alanine ester conjugates were synthesised by reaction with the corresponding halomethylated heterocycles. Photocleavage studies of conjugates in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300 and 350 nm) revealed the quantitative release of the amino acids, the best results being obtained for 8-(chloromethyl)-2-methyl-6-oxo-6H-benzopyrano[6,7-d]oxazole.

Abstract: The synthesis of two new symmetrical disazo direct dyes containing 4,4'-diaminostilbene-2,2'disulphonic acid as middle component and 3-chlorosalicylanilide and 4-chlorosalicylanilide as coupling components are presented. The synthesized dyes were analyzed by thin layer chromatography (TLC), electronic spectra (VIS) and HPLC technique. Their structures were elucidated by FT/IR and ¹³C-NMR spectroscopy. The CIELAB (1976) colour space was used in all the colour measurements for the two disazo stilbene dyes under the CIE recommended illuminants: D65 (natural day light), A (tungsten light), F2 (fluorescent light) and the standard 10° observer respectively. The colour difference (ΔEab*) was calculated against one standard

Abstract: A series of Schiff base ester, 4-{[(4-iodophenyl)imino]methyl}phenyl alkanoates possessing different number of carbon atoms at the terminal alkanoyloxy chain (C_n-1H_2n-1COO-, n = 4, 6, 8, 10, 12, 14) was synthesized. C4 member was found non-mesogenic, whilst C6 to C14 derivatives exhibited enantiotropic smectic A phase with fan-shaped texture. It was found that the length of terminal alkanoyloxy chain influenced the mesomorphic properties.

Abstract: Efficient synthesis, besides other, of dibromide, diazide, diamine and diesters derived from (11R,12R)-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol (3), a chiral bicyclic diol with C₂ symmetry, was developed. Esterification of 3 with saturated and unsaturated carboxylic acids and acids chlorides leads to the corresponding normal-, olefinic- and acetylenic diesters in average yields of 81%. Also more efficient techniques for the preparation of starting diol 3 in higher yields as well as for a very simple separation of DCU from reactions carried out following DCC/DMAP mehod are described.

Abstract: We synthesized a new hybrid organo-inorganic polyoxometalate from Na₂WO₄ and di-sodium salt of para-nitrophenyl ester of phosphoric acid, Na₂C₆H₄NO₂@[PW₁₂O₄₀]. Photochemical activity of the compound towards mandelic acid and isopropyl alcohol was studied. It was shown that the polyoxometalate synthesized behaves itself as a powerful photooxidazing agent and/or a catalyst of the photochemical oxidation of the said H-atom donors by nitrocompound in the presence of oxygen.

Abstract: Condensation of the selectively tosilated N-(2-aminobenzyl)-4-methylbenzenesulfonamide with 2-hydroxybenzaldehyde gives rise to (E)-N-(2-(2- hydroxybenzylideneamino)benzyl)-4-methylbenzenesulfonamide in the solid state, as the crystal structure determined shows, and which in solution shows equilibrium between the acyclic imine and 2-(3-tosyl-1,2,3,4-tetrahydroquinazolin-2-yl)phenol

Abstract: We have generated different resveratrol-coumarin hybrids with the aim of evaluate their biological applications and their pharmacological properties, particularly the inhibitory activity of monoamine oxidase enzyme. According to that, a first series of 3-aryl-4-hydroxycoumarins has been synthesized starting from aryl boronic acids and phenyliodonium zwitterions precursors by a palladium-catalyzed coupling reaction.

Abstract: Condensation of pentaethylenehexamine and 3-bromo-5-chlorosalicylaldehyde yielded the bisimidazolidine Schiff base ligand 5,6'-(1E,1'E)-(2,2'-(3,3'-(ethane-1,2- diyl)bis(2-(3-bromo-5-chloro-2-hydroxyphenyl)imidazolidine-3,1-diyl))bis(ethane- 2,1-diyl))bis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)bis(2-bromo-4- chlorophenol), H₄L. This diimine could be suitably characterised both in the solid state and in solution.

Abstract: Dyes ions have a tendency to self-associate in aqueous solutions. Since almost all textile dyes are applied from aqueous systems, it is important to understand the association of dyes in water, and to determine the number of chemical species presented in the system. The aggregation of the dyes in aqueous solution is influenced by: the dye concentration, electrolyte concentration, and temperature. In the present work, the qualitative and quantitative analysis of the aggregation of two disazo direct dyes (DSA, and DAS) is presented. The molecular aggregation of studied dye has been studied spectrophotometrically in aqueous solutions as a function of dye concentration (10^-6 ÷10^-3 M). In case of DSA dye, in concentration range 1^.10^-6 ÷ 1^.10^-5 M and 5^.10^-5 ÷ 1^.10^-3 M, as the concentration increases, the extinction coefficient at 416.5 nm decreased. Between concentrations 1^.10^-5 ÷ 5^.10^-5 M an increase of extinction coefficient was observed, and the shape of the spectra changed; all this shifts indicate that the molecules are beginning to aggregate. In case of DAS dye, a change in the absorption spectra shape was observed at concentrations bigger than 5^.10^-5 M. From the mathematical obtained data the number of species presented in the system, in domain of concentrations investigated, was determined. The mathematical calculations confirm the experimental data regarding the aggregation of the DSA, and DAN dyes. From the matriceal analysis, the number of chemical species presented in the system (in domain of concentrations studied) was determined to be three in case of DSA dye, respectively four in case of DAN dye.

Abstract: A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.

Abstract: In this paper we report a simple synthetic route to obtain functionalized allyltin derivatives from 1-ethynylcyclohexene (1), through a "one pot" procedure. Radical addition of trineophyltin hydride to 1 leads quantitatively to (Z,E)-1-(2-trineophylstannylvinyl)-cyclohexene (3), a conjugated dienylstannane that, through a [4+2] cycloaddition reaction (Diels -Alder) with activated dienophiles, allows to obtain substituted bicyclic unsaturated products with specific stereochemistry and a trialkylstannyl group in allylic position.

Abstract: In this study, MCM-41-SO₃H has been regarded as an efficient catalyst for the synthesis of aldimines and ketimines by the reaction of carbonyl compounds with primary amines at room temperature in excellent conversion yields.

Abstract: With the aim to find out the best methodology to prepare different series of substituted coumarins, thinking on their pharmacological evaluation, in the present communication we report the synthesis of 3-phenylcoumarin with different number and position of substituent groups in both 3-phenyl and coumarin rings. The substituents in this new scaffold were introduced in the 6 and 8 positions of the coumarin moiety and in 3'and 4' positions of the 3-phenyl ring. The synthesized compounds 1-7, 8 and 9-11 were prepared and characterized by different methodologies. Perkin modified reaction (method A and B) and Palladium-catalyzed synthesis (method C) were the methodologies described in this communication.

Abstract: In the frame of a biotinylation program of biologically active amines we synthesized two amides from 2-phenetylamine and 3,4-dimethoxybenzylamine, that were fully characterized by means of multinuclear NMR spectroscopy.

Abstract: A new and flexible route for the asymmetric synthesis of a variety of alkylated bridged tetrahydro-2-benzazepines has been developed. The key steps are the highly diastereoselective Michael addition of metalated SAMP-hydrazones to α,β-unsaturated esters combined with cyclomethylenation/Mitsunobu coupling reactions to secure the formation of the seven-membered azaheterocycle and of the bridged unit respectively.

Abstract: 1,2-Cyclic sulfamidates undergo novel, efficient and regiospecific intramolecular nucleophilic cleavage with aryllithiated species to provide an entry to poly, diversely and enantiopure N-substituted benzosultams.