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4-(Hydroxymethyl)-6-methoxy-2-oxo-2H-benzo[h]benzopyran-ß-alanine conjugate: synthesis and photocleavage

Centro de Química, Universidade do Minho, Gualtar, 4710-057 Braga, Portugal; * Author to whom correspondence should be addressed.
(This article belongs to the section A. General Organic Synthesis)
Cite this paper as: Soares, A.; Costa, S.; Gonçalves, M. 4-(Hydroxymethyl)-6-methoxy-2-oxo-2H-benzo[h]benzopyran-ß-alanine conjugate: synthesis and photocleavage. In Proceedings of the 13th Int. Electron. Conf. Synth. Org. Chem., 1-30 November 2009; Sciforum Electronic Conferences Series, 2009, a002:1-8.
Abstract: The novel functionalised oxygen heterocycle 4-(hydroxymethyl)-6-methoxy-2-oxo-2H-benzo[h]benzopyran was synthesised and used in the preparation of a fluorescent ß-alanine conjugate. In order to evaluate its photosensitivity, photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300 and 350 nm) was carried out and photocleavage kinetic data were obtained.
Keywords: Photocleavable protecting groups; Benzopyrans; Neurotransmitter amino acids

 

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