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Usage Statistics Cite this paper as: Abass, M.; Ismail, M.; Abdel-Monem, W.; Mayas, A. Substituted Pyridopyrimidinones. Part III. Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one. In Proceedings of the 13th Int. Electron. Conf. Synth. Org. Chem., 1-30 November 2009; Sciforum Electronic Conferences Series, 2009, a018:1-15.
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13th Int. Electron. Conf. Synth. Org. Chem. 2009, a018:1-15
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Substituted Pyridopyrimidinones. Part III. Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo 11757, Egypt;
* Author to whom correspondence should be addressed.
(This article belongs to the section A. General Organic Synthesis)
Abstract: A series of novel bi-heterocyclic ethers, containing 4H-pyrido[1,2-a]pyrimidin-4-one along with other five and six-membered heterocyclic rings, was obtained utilizing ethyl [(4- oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy]acetate (1), [(4-oxo-4H-pyrido[1,2-a]pyrimidin-2- yl)oxy]-acetic acid (2) and/or [(4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy]acetohydrazide (3). Reaction of ester 1 with some ortho-hydroxy aldehydes furnished the corresponding pyridopyrimidyloxypyrones. Reaction of ester 1 or acid 2 with 1,2-diamines led to some imidazoles. Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3.
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