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Usage Statistics Cite this paper as: Gholamipour-Shirazi, A.; Penhoat, M.; Rolando, C. Alkylation of carboxylic acids in a microfluidic device: kinetics parameters determination, Hammett reaction constant measurement and optimization of preparative experiment. In Proceedings of the 13th Int. Electron. Conf. Synth. Org. Chem., 1-30 November 2009; Sciforum Electronic Conferences Series, 2009, a038:1-14.
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13th Int. Electron. Conf. Synth. Org. Chem. 2009, a038:1-14
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Alkylation of carboxylic acids in a microfluidic device: kinetics parameters determination, Hammett reaction constant measurement and optimization of preparative experiment
Université de Lille 1, Sciences et Technologies, UMR CNRS USTL 8009, Organic and Macromolecular Chemistry, FR CNRS USTL 2638, Eugène-Michel CHEVREUL Institute, Villeneuve d’Ascq, France;
* Author to whom correspondence should be addressed.
(This article belongs to the section A. General Organic Synthesis)
Abstract: A new proton sponge 1,8-bis(tetramethylguanidino)naphthalene (TMGN) was utilized for the alkylation of benzoic acid by iodomethane in a continuous flow microsystem. Using this set-up, kinetics of the reaction was determined in different mixing strategies and the Hammett reaction constant was measured. Good performance and efficiency of this procedure were confirmed through several preparative studies.
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