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Usage Statistics Cite this paper as: Kottakota, S.; Harburn, J.; O’Shaughnessy, A.; Gray, M.; Konstanidis, P.; Yakubu, D. Synthesis of 5-BromoVerongamine, an Antibacterial Dibromotyrosine Metabolite from Pseudoceratina sponge. In Proceedings of the 13th Int. Electron. Conf. Synth. Org. Chem., 1-30 November 2009; Sciforum Electronic Conferences Series, 2009, c002:1-7.
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13th Int. Electron. Conf. Synth. Org. Chem. 2009, c002:1-7
Communication
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Synthesis of 5-BromoVerongamine, an Antibacterial Dibromotyrosine Metabolite from Pseudoceratina sponge
Suresh Kottakota, J. Jonathan Harburn * 
, Anthony O’Shaughnessy, Mark Gray, Philppos Konstanidis and Davis Yakubu
, Anthony O’Shaughnessy, Mark Gray, Philppos Konstanidis and Davis YakubuSunderland Pharmacy School, University of Sunderland, Wharncliffe Street, Sunderland, SR1 3SD, UK;
* Author to whom correspondence should be addressed.
(This article belongs to the section C. Bioorganic Chemistry and Natural Products)
Abstract: 5-BromoVerongamine has been successfully synthesized in 2 steps in good yield from readily available starting materials. Structural elucidation has been confirmed through direct comparison with spectroscopic data of isolated natural product. 5-BromoVerongamine has been shown to have moderate bacteriacidal activity against MRSA.
Keywords: marine sponge metabolites, bromotyramine, bromotyrosine, anti-bacterials
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