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Usage Statistics Cite this paper as: Laurent, J.; Stanicki, D.; Huang, T.; Dei-Cas, E.; Pottier, M.; Aliouat, E.; Vanden Eynde, J. Bisbenzamidines as antifungal agents. Are both amidines functions required to observe an anti-Pneumocystis carinii activity?. In Proceedings of the 13th Int. Electron. Conf. Synth. Org. Chem., 1-30 November 2009; Sciforum Electronic Conferences Series, 2009, c008:1-7.
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13th Int. Electron. Conf. Synth. Org. Chem. 2009, c008:1-7
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Bisbenzamidines as antifungal agents. Are both amidines functions required to observe an anti-Pneumocystis carinii activity?
Julien Laurent a, Dimitri Stanicki a, Tien Huang b, Eduardo Dei-Cas c,d, Muriel Pottier c, El- Mouktar Aliouat c,d and Jean Jacques Vanden Eynde a,* 
a University of Mons, Laboratory of Organic Chemistry, Faculty of Sciences, Mons, Belgique;
b Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, New Orleans, USA;
c University of Lille 2, Laboratory of Parasitology, Faculty of Pharmacy, Lille, France;
d Pasteur Institute of Lille, Laboratory of Parasitism Ecology, Lille, France;
* Author to whom correspondence should be addressed.
(This article belongs to the section C. Bioorganic Chemistry and Natural Products)
Abstract: A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl and Nhexyl 4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds with inhibition percentages at 0.1μg/ml of 61(percent) and 56(percent) respectively.
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