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Usage Statistics Cite this paper as: Yenil, N.; Oskay, M.; Kuzu, S.; Ay, E.; Ay, K. Synthesis and antimicrobial activities of 3-O-Methyl-(R)-1,2-O-trichloroethylidene-α-D-xylo-furanuronic acid and 3-O-Methyl-(S)-1,2-O-trichloroethylidene-α-D-xylo-furanuronic acid. In Proceedings of the 13th Int. Electron. Conf. Synth. Org. Chem., 1-30 November 2009; Sciforum Electronic Conferences Series, 2009, c014:1-10.
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13th Int. Electron. Conf. Synth. Org. Chem. 2009, c014:1-10
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Synthesis and antimicrobial activities of 3-O-Methyl-(R)-1,2-O-trichloroethylidene-α-D-xylo-furanuronic acid and 3-O-Methyl-(S)-1,2-O-trichloroethylidene-α-D-xylo-furanuronic acid
a Department of Chemistry, Sciences and Arts Faculty, Celal Bayar University, Manisa 45030, Turkey;
b Department of Biology, Sciences and Arts Faculty, Celal Bayar University, Manisa 45030, Turkey;
* Author to whom correspondence should be addressed.
(This article belongs to the section C. Bioorganic Chemistry and Natural Products)
Abstract: The preparation of 3-O-methyl-1,2-O-(S)-trichloroethylidene-α-D-xylo-furanuronic acid and 3-O-methyl-1,2-O-(R)-trichloroethylidene-α-D-xylo-furanuronic acid starting from β-chloralose and α-chloralose are described. All new products were characterized by 1H NMR, 13C NMR and FTIR. Antibacterial potency of the product (6b) was determined in term of inhibition zone diameter and results showed that this compound showed moderate activity against the tested microorganisms with inhibition zones ranging from 10 to 22 mm.
Keywords: Antimicrobial activity; uronic acid; trichloroethylidene acetals; β-chloralose; α-chloralose
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