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Usage Statistics Cite this paper as: Do, T.; Vo, P.; Tran, T. Synthesis and Comparison of Anti-inflammatory Activity of Chrysin Derivatives. In Proceedings of the 13th Int. Electron. Conf. Synth. Org. Chem., 1-30 November 2009; Sciforum Electronic Conferences Series, 2009, c019:1-6.
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13th Int. Electron. Conf. Synth. Org. Chem. 2009, c019:1-6
Communication
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Synthesis and Comparison of Anti-inflammatory Activity of Chrysin Derivatives
1 on Duc Thang University, Ho Chi Minh City, Vietnam;
2 School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam;
* Author to whom correspondence should be addressed.
(This article belongs to the section C. Bioorganic Chemistry and Natural Products)
Abstract: A series of five chrysin derivatives was synthesized and examinated for their antiinflammatory activities. The in vivo anti-inflammatory activity of synthetic compounds was carried out using the model of carrageenan induced mice paw edema. The results showed that methylation of 5,7- dihydroxyl groups of chrysin resulted to increase the in vivo bioactivity in comparison with the corresponding chrysin derivatives having two free hydroxyl groups. The introduction two halide groups into B ring at 6 and 8 positions of chrysin did not to improve any significant increase positive effect on the in vivo bioactivity.
Keywords: anti-inflammatory activity, chrysin derivatives
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